The crocodilian orthologs of EDDM share many sequence features, including the repeat-rich central domain and the excessive cysteine content material, with avian EDDM. Due to this fact, these features have almost certainly been inherited from the final common ancestor of birds and crocodilians which lived around 240 million years in the past (Kumar et al. 2017) and based on present knowledge, did not have feathers. Apparently, the evolutionary origin of another feather protein, EDCRP, may be traced back to the last common ancestor of extant archosaurs (Holthaus et al. Subsequently, the co-option of epidermal differentiation for Fujifilm Australia new roles as components of feathers seems to be an vital theme, comparable to the co-choice of claw keratins as structural proteins of hair in mammals (Eckhart et al. Taken collectively, our data add EDDM to the catalog of feather proteins, also together with feather CBPs (feather beta-keratins), EDCRP, and EDMTFH, that are encoded by single-coding exon genes throughout the EDC, also called SEDC genes (Strasser et al. 2014). It is thus outstanding that the diversification of SEDC proteins within the EDC of archosaurs offered the molecular substrates for the evolution of feathers.
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